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The use of anti-ED drugs, including the Cialis-type erectile dysfunction drugs, has been growing in China, according to a study published in theJournal of Erectile Dysfunction. In the study, published in the, researchers analyzed data from more than 2,400 men over the age of 40 who suffered from erectile dysfunction from 2003 to 2015. They measured the frequency of erections, duration of erections, and the severity of symptoms. They analyzed data for patients who had at least one symptom of erectile dysfunction (e.g., decreased libido, difficulty maintaining erections) and for the frequency of other symptoms (e.g., ejaculation, loss of libido, ejaculation disorder). The researchers found that the number of ED patients who received Cialis-type erectile dysfunction drugs increased by 0.5 to 3.8 percent per year in a given year. These results were consistent with those of a recent meta-analysis, which estimated that ED patients were 4.4 times more likely to have severe ED and 2.8 times more likely to have other ED symptomatology. Cialis-type erectile dysfunction drugs were found to be associated with a lower incidence of erectile dysfunction in younger men. The study’s findings should help increase awareness of the potential side effects of erectile dysfunction drugs.

In the study, researchers analyzed data from more than 2,400 men over the age of 40 who suffered from erectile dysfunction from 2003 to 2015.

“The results of this study highlight the increasing awareness about ED and the need for effective ED treatment,” said Dr. Jia Zhang, M. D., director of the Division of Sexual Medicine at the University of Shanghai, China, and lead investigator of the study. “The potential benefits of ED treatment should be further explored by clinicians, considering the diverse and complex nature of the disease, including psychological, social, and biological factors.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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Cialis and Other Medicines

Karnoads, M. D.Introduction to Tadalafil (Cialis) and Its Uses.Hyderabad:Nagpur, MaharashtraPunjab, Aligarh, IndiaArakast, Madhya, India4.Punjabi, Punjab, India5.India6.New Delhi, New Caledonia, India7.Jaipur, QUIRE B, Bhind, Uttarakhand, India8.Kanida, Uttarakhand, India9.Sanofi, San Diego, California, U. S.10.Actavis, Mumbai, Karnataka, Maharashtra, Gujarat, Makeriee, Hassan, Khandave, Qureshi, Shokhand, Vaso, Khanda, G anecdosee.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read more about Cialis's side effects.

As with any prescription medication, inform your doctor of any medical conditions you used to get pregnant, or were prescribed one or more of the medications listed here. Cialis can cause some mild side effects. The most common ones are listed below, use them carefully and consult your doctor if you experience these most of the time.

If you had a heart attack or stroke, inform your health care provider that you are taking Cialis. As with all prescription medications, inform your doctor of any medicine you are taking to avoid the effects that may be vision-related.

If you had a heart attack or stroke, let your health care provider that you are taking Cialis do it.

In addition, let your doctor know if you are from Canada, India, the United States, or have been told that you are not permitted to practice in Canada. If you are from this region, you will not be allowed to practice in Canada. Your doctor will initiate a speaking/practice interview with you if they conclude that you are qualified to give speak/practice interviews. This will allow them to assess your ability to understand and comply with all legal requirements.

In addition, let your doctor know if you have high blood pressure, diabetes, or a history of liver problems. Cialis can cause some side effects.

If you have a history of liver disease, tell your health care provider that you are taking Cialis.

In addition, let your doctor know if you are pregnant or plan to become pregnant.

If you have a history of heart problems, let your health care provider that you are taking Cialis do it. As with all prescription medications, inform your health care provider of any medicine you are taking to avoid the effects that may be vision-related.

In addition, let your doctor know if you are a thyroid patient, a man with a history of mental illness, or a man with a history of low blood pressure.

How do I use my Cialis?

Cialis is a drug that you need to take as needed. The usual dose is one tablet once daily, but it can be taken with or without food. If you are taking a higher or lower dose, you can take it with a low dose of the drug. Take it with a low or high dose of Cialis, or with food to reduce the likelihood that you will be given a higher dose than what you are used to. Take a Cialis tablet on the same day, and take the dose on the same day every day. Take it with or after food, as these drugs can have side effects that are more likely to occur in people who take them with a higher dose than what is recommended. Do not take a Cialis pill if you take it with a low or high dose of Cialis. Taking your medicine at the same time each day and having a different dose may increase the risk of side effects and even make them worse.

What are the possible side effects of Cialis?

Some people who take Cialis may experience:

  • Headache
  • Indigestion
  • Nausea
  • Diarrhea
  • Fainting

More serious side effects are rare and can include:

  • Fluid retention
  • Dizziness
  • Muscle pain
  • Chest pain
  • Shortness of breath
  • Vomiting

What if I miss a dose of Cialis?

If you miss a dose of Cialis, take it as soon as you can. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take two doses at once to make up for a missed dose.

If you are taking Cialis daily for a year or longer, you should discuss with your doctor the length of time that it is used and whether any other treatments are needed. Do not change your dose of Cialis without talking to your doctor.

What happens if I overdose?

If you are taking Cialis regularly and you think you may have a Cialis overdose, you should immediately call for medical help if you think you may have a serious overdose. If you cannot or cannot take Cialis, you should get medical help right away.

You can go to the emergency department of your local hospital if you think you may have a serious overdose and they can assess the cause of the problem and make a recommendation for treatment. If you are having trouble breathing or swallowing, call your doctor. Do not stop using any medicine or herbal products without talking to them.

Will I need to take Cialis daily?

The recommended dose of Cialis for daily use is 2.5 mg once a day, taken as needed at approximately the same time each day. However, it is important to remember that Cialis is a prescription drug and should only be taken under the guidance of a healthcare professional. You can also visit a health insurance company or go to the nearest emergency room.

What should I do if I overdose on Cialis?

If you think you may have a serious overdose, call your local poison control center or emergency room right away. If they do not think you need to call immediately, they may increase your dose of Cialis to a higher dose of 50 mg (30 mg) once daily. This is to help you remember to take it.

If you think you may have a serious overdose, you can go to the emergency room right away with a prescription. If you are not sure whether you should be taking Cialis, talk to your doctor or pharmacist.

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